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Search Results for " hmg-coa reductase "

86

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14342	Atorvastatin lactone	HMG-CoA Reductase	Metabolism
	Atorvastatin lactone 是一种 Atorvastatin 的前药。其中 Atorvastatin 是口服具有活力的 3- 羟基 -3- 甲基戊二酰辅酶 A 还原酶抑制剂。
T1487	Fluvastatin sodium XU 62320 sodium,XU-62-320,氟伐他汀钠,Fluvastatin sodium salt	Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Fluvastatin sodium (Fluvastatin sodium salt) salt 是羟甲基戊二酰辅酶 A 还原酶的竞争性抑制剂，IC50为 8 nM。它通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激，是一种常用的降胆固醇剂。
T6450	Clinofibrate 克利贝特,S-8527,Lipoclin	HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Clinofibrate (Lipoclin) 是一种降脂剂，可抑制羟甲基戊二酰辅酶 A 还原酶。它用于控制血液中的高胆固醇和甘油三酯水平。
T6994	SR12813 SR-12813,SR 12813,GW 485801	HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	SR12813 (GW 485801) 是一种人孕烷X 受体激动剂，还是一种 3-羟基-3-甲基-戊二酰辅酶 A 还原酶抑制剂，IC50值为 0.85 μM。
T12092	Monacolin J Antibiotic MB 530A,Lovastatin diol lactone,辛伐他汀内酯二醇	HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Monacolin J (Antibiotic MB 530A) 是一种胆固醇生物合成抑制剂，抑制 HMG-CoA 还原酶的活性。
T79520	HMG-CoA Reductase-IN-1
	HMG-CoA Reductase-IN-1是一种HMG-CoA还原酶抑制剂，显示出高HMGR抑制活性及OATP1B1亲和力，具有pIC50值8.54和pKm值1.98。该化合物适用于高胆固醇血症的研究。
T3116	Atorvastatin hemicalcium salt Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,阿托伐他汀钙,Sortis	Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Atorvastatin hemicalcium salt (Atorvastatin Calcium) 是一种口服有效的 HMG-CoA 还原酶抑制剂，可用作降低胆固醇的药物。它抑制人 SV-SMC 增殖和侵袭，IC50分别为 0.39 μM 和 2.39 μM。
T1676	Rosuvastatin 罗伐他汀,ZD 4522,瑞舒伐他汀	Potassium Channel; HMG-CoA Reductase; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Rosuvastatin (ZD 4522) 是一种抗血脂药，可竞争性抑制羟甲基戊二酰辅酶 A 还原酶，用于降低血浆胆固醇水平和预防心血管疾病。它降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流，IC50为 195 nM，延迟心脏复极化，延长动作电位持续时间和校正 QT 间期间隔。
T2534	Pitavastatin calcium P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104	Apoptosis; Mitophagy; Endogenous Metabolite; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Pitavastatin calcium (NK-104) 是一种羟甲基戊二酰-CoA 还原酶抑制剂。它在 HepG2 细胞中抑制乙酸合成胆固醇的IC50为 5.8 nM。它是高效的肝细胞低密度脂蛋白胆固醇受体诱导剂。具有抗癌活性。
T1510	Rosuvastatin calcium ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium,瑞舒伐他汀钙	Potassium Channel; HMG-CoA Reductase; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Rosuvastatin calcium (ZD4522) 是肝羟甲基戊二酰辅酶 A 还原酶的选择性和竞争性抑制剂，具有抗血脂活性。它降低成熟 hERG 的表达以及热休克蛋白 70 与 hERG 蛋白的相互作用，还降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流，延迟心脏复极化，来延长动作电位持续时间和校正 QT 间期间隔。
T20765	Atorvastatin 阿托伐他汀,阿伐他汀	HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，通过激活肝细胞色素p450加快代谢，具有有效降低血脂的能力。Atorvastatin 以 IC50 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。Atorvastatin 与氯吡格雷同时服用两种可能会导致患者血栓事件增加。
T21405	Fluvastatin Canef,XU-62320,Vastin,Cranoc,Lescol	HMG-CoA Reductase	Metabolism
	Fluvastatin (XU-62320) 是一种具有高效性和竞争性的 HMG-CoA 还原酶抑制剂（IC50 ：8 nM），可通过依赖 Nrf2 通路抑制血管平滑肌细胞免受氧化应激，用于降低血浆胆固醇水平和预防心血管疾病。
T13131	Tert-Buthyl Pitavastatin	HMG-CoA Reductase	Metabolism
	tert-Buthyl Pitavastatin 是 Pitavastatin 的代谢产物。其中Pitavastatin 是HMG-CoA 还原酶抑制剂。
T25285	Dalvastatin RG-12561,RG 12561,RG12561	HMG-CoA Reductase	Metabolism
	Dalvastatin (RG-12561) 是一种可口服的 HMG-CoA 还原酶和降胆固醇合成的抑制剂。Dalvastatin 竞争性地抑制大鼠肝脏HMG-CoA还原酶，IC50值为3.4 nmol / l。 Dalvastatin 在在大鼠实验中，抑制肝切片中的胆固醇生物合成，ED50值为0.9。
T10324	Anhydrosimvastatin Dehydro simvastatin,脱水辛伐他汀	HMG-CoA Reductase	Metabolism
	Anhydrosimvastatin (Dehydro simvastatin) 是 Simvastatin 的一种杂质。其中Simvastatin 是竞争性的 HMG-CoA 还原酶抑制剂。
T24865	Tenivastatin L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid	ROS; HMG-CoA Reductase	Immunology/Inflammation; Metabolism
	Tenivastatin (Simvastatin acid) 是一种抗高脂血症的 HMG-CoA 还原酶抑制剂，抑制活性氧 (ROS) 产生，可用于研究原发性高脂血症。
TQ0045	2-Hydroxy atorvastatin calcium salt	Drug Metabolite	Metabolism
	2-Hydroxy atorvastatin calcium salt 是 Atorvastatin 钙盐的羟基代谢物，Atorvastatin 是一种有效的 HMG-CoA 还原酶抑制剂 (IC50 = 8 nM)。
T12652	(Rac)-5-Keto Fluvastatin 5-Ketofluvastatin,3-Hydroxy-5-Keto Fluvastatin,rac 5-Keto Fluvastatin	Others	Others
	(Rac)-5-Keto Fluvastatin (rac 5-Keto Fluvastatin) 是 Fluvastatin 的杂质，Fluvastatin 是一种 HMG-CoA 还原酶的抑制剂。
T12490	Pitavastatin lactone	Others	Others
	Pitavastatin lactone 是 Pitavastatin 在人体中的主要代谢产物。Pitavastatin 是 HMG-CoA 还原酶竞争性抑制剂。
T20887	Atorvastatin Sodium Lipitor	LDL; Aquaporin; HMG-CoA Reductase	Membrane transporter/Ion channel; Metabolism
	Atorvastatin Sodium (Lipitor) 是一种HMG-CoA 还原酶的竞争性抑制剂，增加肝细胞上低密度脂蛋白（LDL）受体的表达。Atorvastatin sodium 处理抑制水汽蛋白4来减轻缺血性脑水肿。
T26644	Apomine SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A	HMG-CoA Reductase	Metabolism
	Apomine (SR-9223i) 是一种 HMG-CoA-还原酶抑制剂，可在体外促进骨髓瘤细胞的凋亡，并与体内骨髓瘤的调节有关。 Apomine 加速 3-羟基-3-甲基戊二酰-CoA 还原酶的降解并刺激低密度脂蛋白受体活性。 Apomine 通过下调 3-羟基-3-甲基戊二酰-CoA 还原酶来增强洛伐他汀对骨髓瘤细胞的抗肿瘤作用。
T19918	Lovastatin hydroxy acid sodium 6-α-Methylcompactin sodium,Lovastatin Na,Lovastatin Sodium,Mevinolin sodium
	Lovastatin Sodium is an HMG-CoA reductase inhibitor.
T14931	Cerivastatin	Others	Others
	Cerivastatin is a highly potent, well-tolerated, and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM/L). Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition with anti-cancer effect. Cerivastatin r
T11572	HMG499	HMG-CoA Reductase	Metabolism
	HMG499是有效，选择性的HMG-CoA 还原酶抑制剂，EC50为 0.41 μM。HMG499可消除他汀类药物诱导的HMGCR 积聚，并且降低血清胆固醇水平，减少动脉粥样硬化。
T24323	L 669262 L-669,262,L 669,262,L669,262,L-669262,L669262
	L 669262 is a potent inhibitor of HMG-CoA reductase.
T70633	GR-92549
	GR-92549 is an HMG-CoA reductase inhibitor.
T10070	2'-Ethyl Simvastatin	HMG-CoA Reductase	Metabolism
	2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
T21080	(3S,5S)-Atorvastatin ent-Atorvastatin,3S,5S-Atorvastatin,(3S,5S)-阿托伐他汀
	ent-Atorvastatin is a selective and competitive inhibitor of HMGCR (HMG-CoA reductase).
T26044	Rawsonol
	Rawsonol is a HMG-CoA reductase inhibitor from the tropical green alga Avrainvillea rawsoni.
T71040	GR-95030X
	GR-95030X is a a novel HMG-CoA reductase inhibitor.
T28440	PPD 10558 PPD-10558,RBx10558,RBx-10558,PPD10558,RBx 10558
	PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia.
T13380	(Z)-Pitavastatin calcium	Others	Others
	(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent of hydroxymethylglutaryl-CoA (HMG-CoA) reductase.
T22405	Pravastatin	Others	Others
	Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.
T69006	Atorvastatin lysine
	Atorvastatin lysine is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor.
T10132	(3S,5S)-Pitavastatin calcium	Others	Others
	(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.
T10136	4-Acetylsimvastatin	Others	Others
	4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM).
T21042	Fluvastatin Methyl Ester
	Fluvastatin Methyl Ester is a precursor of Fluvastatin, a blocker of the enzyme HMG-CoA reductase in liver.
T10130	(3S,5R)-Pitavastatin calcium	Others	Others
	(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.
T10131	(3S,5R)-Rosuvastatin	Others	Others
	(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).
T10126	(3R,5R)-Rosuvastatin	Others	Others
	(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).
T24461	Mevinolinic acid L 154819,L-154819,MK 819,MSD 803 acid,Monacolinic K acid
	Mevinolinic acid is an active metabolite of Lovastatin. Lovastatin is an HMG-CoA reductase inhibitor.
T21363	Atorvastatin calcium trihydrate CI-981,atorvastatin, calcium salt,CI981,Atorvastatin,CI 981
	Atorvastatin is used to inhibits HMG-CoA reductase for lowering blood cholesterol and for prevention of events associated with cardiovascular disease.
T68566	Pitavastatin methyl ester
	Pitavastatin methyl ester is the methyl ester derivative of Pitavastatin -- a competitive inhibitor of HMG-CoA reductase and an anti-lipemic agent.
T40913	3α-Hydroxy pravastatin sodium
	3α-Hydroxy pravastatin sodium, the primary metabolite of Pravastatin, is a potent competitive inhibitor of HMG-CoA reductase.
T70419	Cerivastatin lactone
	Cerivastatin lactone is a metabolite of a competitive inhibitor of HMG-CoA reductase, Cerivastatin. Cerivastatin lactone shows inhibitory effects on CYP3A4/5 activity.
T71705	Glenvastatin
	Glenvastatin 是一种HMG-CoA 还原酶抑制剂，具有吡啶基结构。
T38249	2-Hydroxy atorvastatin lactone
	2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].
T10401	Atorvastatin acetonide	Others	Others
	Atorvastatin acetonide is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
T40557	Simvastatin Acyl-β-D-glucuronide
	Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.
T10767	Cerivastatin sodium	HMG-CoA Reductase	Metabolism
	Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition.

化合物

Atorvastatin lactone

Cat.No: T14342

Target: HMG-CoA Reductase

Fluvastatin sodium

Cat.No: T1487

Synonym: XU 62320 sodium,XU-62-320,氟伐他汀钠,Fluvastatin sodium salt

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Cat.No: T6450

Synonym: 克利贝特,S-8527,Lipoclin

Target: HMG-CoA Reductase, Autophagy

Cat.No: T6994

Synonym: SR-12813,SR 12813,GW 485801

Target: HMG-CoA Reductase, Autophagy

Cat.No: T12092

Synonym: Antibiotic MB 530A,Lovastatin diol lactone,辛伐他汀内酯二醇

Target: HMG-CoA Reductase, Autophagy

HMG-CoA Reductase-IN-1

Cat.No: T79520

Atorvastatin hemicalcium salt

Cat.No: T3116

Synonym: Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,阿托伐他汀钙,Sortis

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Cat.No: T1676

Synonym: 罗伐他汀,ZD 4522,瑞舒伐他汀

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

Pitavastatin calcium

Cat.No: T2534

Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104

Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Rosuvastatin calcium

Cat.No: T1510

Synonym: ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium,瑞舒伐他汀钙

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

Cat.No: T20765

Synonym: 阿托伐他汀,阿伐他汀

Target: HMG-CoA Reductase, Autophagy

Cat.No: T21405

Synonym: Canef,XU-62320,Vastin,Cranoc,Lescol

Target: HMG-CoA Reductase

Tert-Buthyl Pitavastatin

Cat.No: T13131

Target: HMG-CoA Reductase

Cat.No: T25285

Synonym: RG-12561,RG 12561,RG12561

Target: HMG-CoA Reductase

Anhydrosimvastatin

Cat.No: T10324

Synonym: Dehydro simvastatin,脱水辛伐他汀

Target: HMG-CoA Reductase

Cat.No: T24865

Synonym: L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid

Target: ROS, HMG-CoA Reductase

2-Hydroxy atorvastatin calcium salt

Cat.No: TQ0045

Target: Drug Metabolite

(Rac)-5-Keto Fluvastatin

Cat.No: T12652

Synonym: 5-Ketofluvastatin,3-Hydroxy-5-Keto Fluvastatin,rac 5-Keto Fluvastatin

Target: Others

Pitavastatin lactone

Cat.No: T12490

Target: Others

Atorvastatin Sodium

Cat.No: T20887

Synonym: Lipitor

Target: LDL, Aquaporin, HMG-CoA Reductase

Cat.No: T26644

Synonym: SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A

Target: HMG-CoA Reductase

Lovastatin hydroxy acid sodium

Cat.No: T19918

Synonym: 6-α-Methylcompactin sodium,Lovastatin Na,Lovastatin Sodium,Mevinolin sodium

Cat.No: T14931

Target: Others

Cat.No: T11572

Target: HMG-CoA Reductase

Cat.No: T24323

Synonym: L-669,262,L 669,262,L669,262,L-669262,L669262

Cat.No: T70633

2'-Ethyl Simvastatin

Cat.No: T10070

Target: HMG-CoA Reductase

(3S,5S)-Atorvastatin

Cat.No: T21080

Synonym: ent-Atorvastatin,3S,5S-Atorvastatin,(3S,5S)-阿托伐他汀

Cat.No: T26044

Cat.No: T71040

Cat.No: T28440

Synonym: PPD-10558,RBx10558,RBx-10558,PPD10558,RBx 10558

(Z)-Pitavastatin calcium

Cat.No: T13380

Target: Others

Cat.No: T22405

Target: Others

Atorvastatin lysine

Cat.No: T69006

(3S,5S)-Pitavastatin calcium

Cat.No: T10132

Target: Others

4-Acetylsimvastatin

Cat.No: T10136

Target: Others

Fluvastatin Methyl Ester

Cat.No: T21042

(3S,5R)-Pitavastatin calcium

Cat.No: T10130

Target: Others

(3S,5R)-Rosuvastatin

Cat.No: T10131

Target: Others

(3R,5R)-Rosuvastatin

Cat.No: T10126

Target: Others

Mevinolinic acid

Cat.No: T24461

Synonym: L 154819,L-154819,MK 819,MSD 803 acid,Monacolinic K acid

Atorvastatin calcium trihydrate

Cat.No: T21363

Synonym: CI-981,atorvastatin, calcium salt,CI981,Atorvastatin,CI 981

Pitavastatin methyl ester

Cat.No: T68566

3α-Hydroxy pravastatin sodium

Cat.No: T40913

Cerivastatin lactone

Cat.No: T70419

Cat.No: T71705

2-Hydroxy atorvastatin lactone

Cat.No: T38249

Atorvastatin acetonide

Cat.No: T10401

Target: Others

Simvastatin Acyl-β-D-glucuronide

Cat.No: T40557

Cerivastatin sodium

Cat.No: T10767

Target: HMG-CoA Reductase

Cat. No.	Product Name	Target	Signaling Pathways
TN1733	Hesperetin 7-O-glucoside	Anti-infection; Antibacterial; HMG-CoA Reductase	Metabolism; Microbiology/Virology
	Hesperetin 7-O-glucoside 是通过 Hesperidin 的酶促转化产生的一种人 HMG-CoA 还原酶抑制剂，具有降压作用，可抑制幽门螺杆菌的生长。
TN1438	beta-Amyrin acetate beta-香树脂醇乙酸酯	Antioxidant; HMG-CoA Reductase; Epoxide Hydrolase; Antifungal	Metabolism; Microbiology/Virology; oxidation-reduction
	beta-Amyrin acetate 抑制 HMG-CoA 还原酶 (HMGCR) 和 sEH 活性，IC50 为 3.4 μM。 beta-Amyrin acetate 具有抗炎、抗真菌、抗氧化和抗高血脂活性。
T1207	Lovastatin MK-803,洛伐他汀,Mevinolin	Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Lovastatin (MK-803) 是一种 HMG-CoA 还原酶抑制剂，用于降低胆固醇。
T0683	Mevastatin Compactin,ML236B,美伐他汀	Apoptosis; Antibacterial; Antibiotic; HMG-CoA Reductase; Autophagy; Lipid	Apoptosis; Autophagy; Metabolism; Microbiology/Virology
	Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药，可诱导细胞凋亡，将癌细胞阻滞在 G0/G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性，用于心血管疾病的研究。
T1664	Meglutol Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托	Endogenous Metabolite; HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Meglutol (3-Hydroxy-3-methylglutaric acid) 是一种抗血脂剂，可降低胆固醇、甘油三酯、血清 β-脂蛋白和磷脂。它抑制胆固醇生物合成中的限速酶羟甲基戊二酰辅酶 A 还原酶的活性。
T0672	Pravastatin sodium CS-514 Sodium,普伐他汀钠,CS-514 (sodium)	Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Pravastatin sodium (CS-514 (sodium)) 是一种 HMG-CoA 还原酶抑制剂，抑制甾醇合成，IC50 为 5.6 μM。
T0687	Simvastatin 辛伐他汀,MK-0733,MK 733	Apoptosis; Mitophagy; Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM)，具有口服活性。Simvastatin 具有降血脂活性，可以抑制肝脏产生胆固醇，还可以用于预防心血管疾病。
TN6715	7-Ketocholesterol	Others	Others
	7-Ketocholesterol 是胆固醇的代谢物。
T4717	25-Hydroxycholesterol 25-羟基胆固醇,25-羟基胆甾醇	Others; Endogenous Metabolite; HMG-CoA Reductase	Metabolism; Others
	25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体激活而分泌。它有效抑制 B 细胞产生 IgA，EC50约为 65 nM。
TN2111	Prunin Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷	Phosphatase; Anti-infection; Virus Protease	Metabolism; Microbiology/Virology
	Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B，IC50值为 5.5 μM。
T75626	Ganoderenic acid K
	Ganoderenic acid K，一种从灵芝子实体分离得到的天然产物，对HMG-CoA还原酶(HMGCR)显示出强抑制作用，IC50值为16.5 μM。
T35400	β-Muricholic Acid β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid
	β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

天然产物

Hesperetin 7-O-glucoside

Cat.No: TN1733

Target: Anti-infection, Antibacterial, HMG-CoA Reductase

beta-Amyrin acetate

Cat.No: TN1438

Synonym: beta-香树脂醇乙酸酯

Target: Antioxidant, HMG-CoA Reductase, Epoxide Hydrolase, Antifungal

Cat.No: T1207

Synonym: MK-803,洛伐他汀,Mevinolin

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Cat.No: T0683

Synonym: Compactin,ML236B,美伐他汀

Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid

Cat.No: T1664

Synonym: Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托

Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Pravastatin sodium

Cat.No: T0672

Synonym: CS-514 Sodium,普伐他汀钠,CS-514 (sodium)

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Cat.No: T0687

Synonym: 辛伐他汀,MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

7-Ketocholesterol

Cat.No: TN6715

Target: Others

25-Hydroxycholesterol

Cat.No: T4717

Synonym: 25-羟基胆固醇,25-羟基胆甾醇

Target: Others, Endogenous Metabolite, HMG-CoA Reductase

Cat.No: TN2111

Synonym: Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷

Target: Phosphatase, Anti-infection, Virus Protease

Ganoderenic acid K

Cat.No: T75626

β-Muricholic Acid

Cat.No: T35400

Synonym: β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid

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